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Dr. Zachary Rubin, MD

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Specializes in: Allergy & Immunology

Case Western Reserve University School of Medicine (2015)

Professional interests include: asthma, eczema, allergies

24600 W. 127th Street Building B Suite 110
Plainfield, IL 60585

(815) 609-8286

Dr. Zachary Rubin, MD is an allergist and immunologist in Naperville, IL specializing in allergy & immunology. He graduated from Case Western Reserve University School of Medicine in 2015 and has 11 years of experience. Dr. Zachary Rubin, MD is affiliated with Endeavor Health.

Office Locations

Endeavor Health

1220 Hobson Road Suite 114
Naperville, IL 60540

(630) 961-2960

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Endeavor Health

24600 W. 127th Street Building B Suite 110
Plainfield, IL 60585

(815) 609-8286

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Endeavor Health

360 W Butterfield Road Suite 140
Elmhurst, IL 60126

(630) 574-0460

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Endeavor Health

6800 S. Main Street Suite 110
Downers Grove, IL 60516

(630) 789-0575

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1 Barnes Jew Hosp Plaza
Saint Louis, MO 63110

(314) 362-5000

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1740 W Taylor Street
Chicago, IL 60612

1-866-600-2273

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Some issues Dr. Zachary Rubin, MD can help you with:

Asthma

Asthma is a chronic lung disease where the tissue and airways of the lungs become extremely sensitive to certain substances. When these substances are breathed in, the lungs become inflamed. The muscles around the airways tighten and squeeze the lungs, and passages within the lungs swell and tighten. The airways themselves produce mucus, which further clogs the tightened, swollen airways. A person having an asthma attack finds it very difficult to breathe, and a severe attack can even be fatal.

Asthma affects people of all ages, but people with asthma are most often diagnosed as children. Symptoms can include wheezing, a tight feeling in the chest, shortness of breath, and coughing. Some people have mild symptoms all the time, and some people have no symptoms at all, but everyone with asthma is susceptible to occasional severe attacks or flare-ups of symptoms when they are exposed to triggers. Triggers vary widely but can include:

Allergens (dust mites, pet fur, mold, pollen, grass)
Irritants (smoke, pollution, dust, chemicals)
Viral infections
Physical activity, especially outdoors
Certain medications or chemicals in foods (aspirin, sulfites)

Treatment for most asthma patients involves three steps. Patients learn what their asthma triggers are and avoid them. They take a daily control medication, usually an inhaled corticosteroid, to reduce inflammation in the lungs. Also, they have rescue medication with them at all times to take in case of a severe attack. These quick-acting inhaled medications relax the muscles around the airways and allow the lungs to open up for air.

There is no cure for asthma, but with treatment it should not interfere with daily life and activities.

In The News (see more mentions in the news)

“But about two-thirds of children with allergies are diagnosed by age 3, said Dr. Zachary Rubin, a pediatric allergist in Illinois.”—"Peanut Allergies Have Plummeted in Children, Study Shows", New York Times, October 2025

“Dr. Zachary Rubin, a double board-certified pediatrician who specializes in immunology and allergy treatment, said in a Substack post that Ladapo s words are "a calculated move in the ongoing...”—"Florida s move to end vaccine mandates may deepen skepticism in Black communities, health experts warn", CNN, September 2025

“Popular medical content creator Dr. Zachary E. Rubin, a pediatrician certified in allergy and immunology, shared a TikTok video in which he explained the Florida outbreak is a "result of the lies...”—"Raw Milk Sold For 'Non-Human Consumption' Linked To Florida Outbreak", Huff Post, August 2025

Noteworthy Medicare Patient Procedures Performed by Dr. Zachary Rubin, MD in 2023

Click on any procedure below to see further details on volume and pricing among Medicare patients.

Top 5%

By Affordability:

allergen immunotherapy

allergy skin testing

allergy testing

immunotherapy

percutaneous allergy test

skin testing

subcutaneous allergen immunotherapy

In 2023, Dr. Zachary Rubin, MD had a list price for allergen immunotherapy, allergy skin testing, allergy testing, immunotherapy, percutaneous allergy test, skin testing, and subcutaneous allergen immunotherapy (allergy shots) that was lower than the list prices billed to Medicare by 95% of providers in related specialties within Illinois. Actual amounts paid by patients can vary widely depending on a number of factors, including insurance coverage. A lower list price, however, might mean lower fees when paying without insurance.

Top 10%

By Volume:

subcutaneous allergen immunotherapy

In 2023, Dr. Zachary Rubin, MD performed more subcutaneous allergen immunotherapy (allergy shots) procedures for Medicare patients than 90% of providers in related specialties within Illinois.

Medicare Procedure and Patient Information

2021 Medicare Procedure Volume

The top procedures that Dr. Zachary Rubin, MD treated as an allergist and immunologist in Naperville, IL during 2021 were immunotherapy, injections, skin testing and allergy testing.

Volume of procedures performed by Dr. Zachary Rubin, MD for Medicare patients.

allergy testing	76
doctor visit	25
immunotherapy	606
injections	606
skin testing	76

2021 Medicare Patient Data

Information about Medicare patients treated by Dr. Zachary Rubin, MD.

**Gender**
Male	61
Female	74

**Ethnicity**
Non-Hispanic White	116
Black	0
Hispanic	0
Asian	0
Other	0
Native American	0

**Age**
From 65 to 74	81
From 75 to 84	41
85 and over	0
Less than 65	0

Conditions of Medicare patients treated by Dr. Zachary Rubin, MD in 2021

Hypertension	56
High Cholesterol	64
Stroke	0
Ischemic Heart Disease	20
Depression	15
Chronic Kidney Disease	19
Asthma	16
Osteoperosis	12
Atrial Fibrilation	0
Heart Failure	0
Chronic Obstructive Pulmonary Disease	8
Diabetes	23
Dementia	0
Cancer	9

Medicare Procedure and Patient Information

2022 Medicare Procedure Volume

The top procedures that Dr. Zachary Rubin, MD treated as an allergist and immunologist in Naperville, IL during 2022 were immunotherapy, injections, skin testing and minimally invasive procedures.

Volume of procedures performed by Dr. Zachary Rubin, MD for Medicare patients.

allergy testing	325
doctor visit	61
immunotherapy	963
injections	963
minimally invasive procedures	325
skin testing	325

2022 Medicare Patient Data

Information about Medicare patients treated by Dr. Zachary Rubin, MD.

**Gender**
Male	69
Female	107

**Ethnicity**
Non-Hispanic White	154
Black	0
Hispanic	0
Asian	0
Other	0
Native American	0

**Age**
From 65 to 74	101
From 75 to 84	59
85 and over	0
Less than 65	0

Conditions of Medicare patients treated by Dr. Zachary Rubin, MD in 2022

Hypertension	60
High Cholesterol	75
Stroke	0
Ischemic Heart Disease	15
Depression	14
Chronic Kidney Disease	14
Asthma	30
Osteoperosis	16
Atrial Fibrilation	7
Heart Failure	0
Chronic Obstructive Pulmonary Disease	11
Diabetes	21
Dementia	0
Cancer	15

Medicare Procedure and Patient Information

Average Medicare Procedure Volume From 2021 - 2022

Volume of procedures performed by Dr. Zachary Rubin, MD for Medicare patients.

The highest averages for the top procedures that Dr. Zachary Rubin, MD treated as an allergist and immunologist in Naperville, IL were immunotherapy, injections, minimally invasive procedures and skin testing.

allergy testing	200
doctor visit	43
immunotherapy	784
injections	784
minimally invasive procedures	325
skin testing	200

Average Medicare Patient Data From 2021 - 2022

Information about Medicare patients treated by Dr. Zachary Rubin, MD.

**Gender**
Male	65
Female	90

**Ethnicity**
Black / African American	0
Asian / Pacific Islander	0
Non-Hispanic White	135
Native American / Alaskan Native	0
Hispanic	0
Other	0

**Age**
75 to 84	50
85 and over	0
Less than 65	0
65 to 74	91

Average of Total of Conditions of Medicare patients treated by Dr. Zachary Rubin, MD From 2021 - 2022

The highest averages of the most common conditions of Medicare patients that Dr. Zachary Rubin, MD treated were high cholesterol, hypertension, asthma and diabetes.

Hypertension	58
High Cholesterol	69
Stroke	0
Ischemic Heart Disease	17
Depression	14
Chronic Kidney Disease	16
Asthma	23
Osteoporosis	14
Heart Failure	0
Chronic Obstructive Pulmonary Disease	9
Diabetes	22
Atrial Fibrillation	3
Dementia	0
Cancer	12

Education & Training

Dr. Zachary Rubin, MD graduated from Case Western Reserve University School of Medicine in 2015. He is certified by the American Board of Allergy and Immunology and has a state license in Illinois.

Medical School: Case Western Reserve University School of Medicine (2015)

Board Certification: American Board of Allergy and Immunology (2020)

Licensed In: Illinois

Affiliations & Hospitals

Dr. Zachary Rubin, MD is associated with these hospitals and organizations:

Endeavor Health

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General Payments

These charts describe general payments received by Dr. Zachary Rubin, MD. Doctors may receive payments for a number of reasons, including meal compensation, travel compensation, and consulting.

**Payments by Company**
AstraZeneca Pharmaceuticals LP	$12,662 FASENRA $120	TEZSPIRE $110	AIRSUPRA $22	BREZTRI $14	$12,395
GlaxoSmithKline, LLC.	$624 NUCALA $451	TRELEGY ELLIPTA $173
GENZYME CORPORATION	$570 NO PRODUCT DISCUSSED $400	DUPIXENT $170
Regeneron Healthcare Solutions, Inc.	$341 DUPIXENT $341
SANOFI-AVENTIS U.S. LLC	$165 DUPIXENT $165
Other	$758 XOLAIR $153	Xhance $111	AirDuo Digihaler $94	SPIRIVA RESPIMAT $85	Auvi-Q $58	Other $258

**Types of Payments**
Consulting Fee	$11,400
Food and Beverage	$2,433
Travel and Lodging	$788
Grant	$400
Education	$99

Biography

Dr. Zachary Rubin is a specialist in allergy & immunology. He studied medicine at Case Western Reserve University School of Medicine. His clinical interests include asthma, eczema, and allergies. Dr. Rubin is professionally affiliated with Endeavor Health.