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Dr. Mark S. Box, MD

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Specializes in: Adult Rheumatology

University of Missouri-Columbia School of Medicine

Professional interests include: Sjogren's syndrome, lupus, psoriatic arthritis, and more.

1010 Carondelet Drive #224a
Kansas City, MO 64114

(913) 563-6644

Dr. Mark S. Box, MD is a rheumatologist in Kansas City, MO specializing in adult rheumatology. He graduated from University of Missouri-Columbia School of Medicine. Dr. Mark S. Box, MD is affiliated with St. Joseph Medical Center and Signature Medical Group.

Office Locations

Signature Medical Group

1010 Carondelet Drive #224a
Kansas City, MO 64114

(913) 563-6644

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Some issues Dr. Mark S. Box, MD can help you with:

Autoimmune Diseases

An autoimmune disorder happens when the immune system mistakenly attacks the tissues of its own body, causing symptoms of illness. There are more than 80 different types of autoimmune disorders. While some are very rare, others are fairly common. Combined, autoimmune disorders are one of the leading causes of death and disability in the United States, affecting approximately 24 million people.

A properly working immune system identifies foreign substances in the body that might cause illness, such as bacteria and viruses. The immune system then creates antibodies which attack the foreign substances, neutralizing them and keeping the body safe. In people with autoimmune disorders, something goes wrong with this process. For reasons that are not fully understand, the immune system creates antibodies to attack the patient's own tissues.

Symptoms of an autoimmune disorder depend on which tissue is being attacked by the immune system, but common symptoms of autoimmune disease include fever, fatigue, and a general feeling of just not being well. Autoimmune disorders are more common in women than in men, and they may run in families. Autoimmune disorders can affect various parts of the body such as blood vessels, connective tissue, endocrine glands, joints, muscles, red blood cells, skin, and many others.

It is common to have more than one autoimmune disorder at a time. Most are chronic, or life-long illnesses, although they may come and go in flares. Treatment for autoimmune disorders depends on which part of the body is being attacked. For example:

A type 1 diabetic whose pancreas has been damaged will need insulin.
A person with Hashimoto's whose thyroid has been damaged will need replacement thyroid hormones.
Someone with Sjogren's syndrome will need eye drops and mouth rinses to replace tears and saliva.

Many autoimmune disorders of all kinds are treated with immune-suppressing medications, such as corticosteroids (e.g. prednisone) to reduce the effect of the immune system.

Noteworthy Medicare Patient Procedures Performed by Dr. Mark S. Box, MD in 2023

Click on any procedure below to see further details on volume and pricing among Medicare patients.

Top 5%

By Volume:

biological response modifier therapy

flu shot

intravenous infusion therapy

intravenous chemotherapy

In 2023, Dr. Mark S. Box, MD performed more biological response modifier (BRM) therapy, flu shot, intravenous infusion therapy, and intravenous (IV) chemotherapy procedures for Medicare patients than 95% of providers in related specialties within Missouri.

Top 10%

By Volume:

major joint aspiration

major joint injection

In 2023, Dr. Mark S. Box, MD performed more major joint aspiration, and major joint injection procedures for Medicare patients than 90% of providers in related specialties within Missouri.

Medicare Procedure and Patient Information

2012 Medicare Procedure Volume

The top procedures that Dr. Mark S. Box, MD treated as a rheumatologist in Kansas City, MO during 2012 were lab tests, blood draw, minimally invasive procedures and chemotherapy.

Volume of procedures performed by Dr. Mark S. Box, MD for Medicare patients.

aspiration	256
biological response modifier (BRM) therapy	691
blood draw	1372
chemotherapy	691
diabetes management	63
doctor visit	2389
hospital care	23
injections	329
inpatient care	23
lab tests	5159
minimally invasive procedures	792
musculoskeletal imaging	46
pain management	42
preventive care	358
thoracic (chest) imaging	14
thyroid function tests	141
vaccines	108
X-rays	60

Medicare Procedure and Patient Information

2013 Medicare Procedure Volume

The top procedures that Dr. Mark S. Box, MD treated as a rheumatologist in Kansas City, MO during 2013 were lab tests, blood draw, minimally invasive procedures and chemotherapy.

Volume of procedures performed by Dr. Mark S. Box, MD for Medicare patients.

aspiration	249
biological response modifier (BRM) therapy	812
blood draw	1351
chemotherapy	812
diabetes management	59
doctor visit	2457
injections	308
lab tests	5254
minimally invasive procedures	885
musculoskeletal imaging	42
pain management	33
preventive care	371
thoracic (chest) imaging	20
thyroid function tests	163
vaccines	116
X-rays	62

2013 Medicare Patient Data

Information about Medicare patients treated by Dr. Mark S. Box, MD.

**Gender**
Male	153
Female	605

**Ethnicity**
Non-Hispanic White	644
Black	89
Hispanic	12
Asian	0
Other	0
Native American	0

**Age**
From 65 to 74	269
From 75 to 84	182
85 and over	68
Less than 65	239

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2013

Hypertension	59
High Cholesterol	49
Stroke	4
Ischemic Heart Disease	27
Depression	21
Chronic Kidney Disease	16
Asthma	9
Osteoperosis	17
Atrial Fibrilation	10
Heart Failure	11
Chronic Obstructive Pulmonary Disease	15
Diabetes	23
Dementia	7
Cancer	7

Medicare Procedure and Patient Information

2014 Medicare Procedure Volume

The top procedures that Dr. Mark S. Box, MD treated as a rheumatologist in Kansas City, MO during 2014 were lab tests, blood draw, minimally invasive procedures and chemotherapy.

Volume of procedures performed by Dr. Mark S. Box, MD for Medicare patients.

aspiration	266
biological response modifier (BRM) therapy	802
blood draw	1311
chemotherapy	802
diabetes management	65
doctor visit	2542
injections	333
lab tests	5259
minimally invasive procedures	873
musculoskeletal imaging	35
pain management	40
preventive care	393
thoracic (chest) imaging	17
thyroid function tests	176
vaccines	134
X-rays	52

2014 Medicare Patient Data

Information about Medicare patients treated by Dr. Mark S. Box, MD.

**Gender**
Male	157
Female	621

**Ethnicity**
Non-Hispanic White	659
Black	90
Hispanic	14
Asian	0
Other	0
Native American	0

**Age**
From 65 to 74	289
From 75 to 84	180
85 and over	64
Less than 65	245

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2014

Hypertension	60
High Cholesterol	49
Stroke	4
Ischemic Heart Disease	29
Depression	24
Chronic Kidney Disease	17
Asthma	10
Osteoperosis	15
Atrial Fibrilation	9
Heart Failure	13
Chronic Obstructive Pulmonary Disease	18
Diabetes	22
Dementia	8
Cancer	6

Medicare Procedure and Patient Information

2015 Medicare Procedure Volume

The top procedures that Dr. Mark S. Box, MD treated as a rheumatologist in Kansas City, MO during 2015 were lab tests, blood draw, minimally invasive procedures and chemotherapy.

Volume of procedures performed by Dr. Mark S. Box, MD for Medicare patients.

aspiration	192
biological response modifier (BRM) therapy	573
blood draw	1241
chemotherapy	573
diabetes management	67
doctor visit	2440
injections	237
lab tests	5335
minimally invasive procedures	792
musculoskeletal imaging	39
pain management	30
preventive care	355
thoracic (chest) imaging	19
thyroid function tests	159
vaccines	81
X-rays	58

2015 Medicare Patient Data

Information about Medicare patients treated by Dr. Mark S. Box, MD.

**Gender**
Male	320
Female	1220

**Ethnicity**
Non-Hispanic White	1302
Black	174
Hispanic	32
Asian	0
Other	0
Native American	0

**Age**
From 65 to 74	604
From 75 to 84	354
85 and over	130
Less than 65	452

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2015

Hypertension	61
High Cholesterol	51
Stroke	5
Ischemic Heart Disease	30
Depression	28
Chronic Kidney Disease	21
Asthma	15
Osteoperosis	18
Atrial Fibrilation	9
Heart Failure	13
Chronic Obstructive Pulmonary Disease	16
Diabetes	23
Dementia	8
Cancer	8

Medicare Procedure and Patient Information

2016 Medicare Procedure Volume

The top procedures that Dr. Mark S. Box, MD treated as a rheumatologist in Kansas City, MO during 2016 were lab tests, blood draw, minimally invasive procedures and chemotherapy.

Volume of procedures performed by Dr. Mark S. Box, MD for Medicare patients.

aspiration	266
biological response modifier (BRM) therapy	489
blood draw	1301
chemotherapy	489
diabetes management	54
doctor visit	2444
injections	339
lab tests	5614
minimally invasive procedures	786
musculoskeletal imaging	47
pain management	37
preventive care	401
thoracic (chest) imaging	16
thyroid function tests	206
vaccines	93
X-rays	63

2016 Medicare Patient Data

Information about Medicare patients treated by Dr. Mark S. Box, MD.

**Gender**
Male	170
Female	608

**Ethnicity**
Non-Hispanic White	650
Black	92
Hispanic	14
Asian	0
Other	0
Native American	0

**Age**
From 65 to 74	319
From 75 to 84	177
85 and over	72
Less than 65	210

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2016

Hypertension	62
High Cholesterol	52
Stroke	6
Ischemic Heart Disease	28
Depression	28
Chronic Kidney Disease	26
Asthma	22
Osteoperosis	20
Atrial Fibrilation	10
Heart Failure	13
Chronic Obstructive Pulmonary Disease	17
Diabetes	24
Dementia	9
Cancer	7

Medicare Procedure and Patient Information

2017 Medicare Procedure Volume

The top procedures that Dr. Mark S. Box, MD treated as a rheumatologist in Kansas City, MO during 2017 were lab tests, blood draw, minimally invasive procedures and chemotherapy.

Volume of procedures performed by Dr. Mark S. Box, MD for Medicare patients.

aspiration	248
biological response modifier (BRM) therapy	453
blood draw	935
chemotherapy	453
diabetes management	51
doctor visit	2366
injections	293
lab tests	3929
minimally invasive procedures	787
musculoskeletal imaging	27
pain management	18
preventive care	229
thyroid function tests	111
X-rays	27

2017 Medicare Patient Data

Information about Medicare patients treated by Dr. Mark S. Box, MD.

**Gender**
Male	159
Female	591

**Ethnicity**
Non-Hispanic White	633
Black	83
Hispanic	14
Asian	0
Other	0
Native American	0

**Age**
From 65 to 74	325
From 75 to 84	167
85 and over	65
Less than 65	193

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2017

Hypertension	65
High Cholesterol	50
Stroke	4
Ischemic Heart Disease	31
Depression	34
Chronic Kidney Disease	29
Asthma	10
Osteoperosis	22
Atrial Fibrilation	11
Heart Failure	15
Chronic Obstructive Pulmonary Disease	18
Diabetes	24
Dementia	11
Cancer	8

Medicare Procedure and Patient Information

2018 Medicare Procedure Volume

The top procedures that Dr. Mark S. Box, MD treated as a rheumatologist in Kansas City, MO during 2018 were minimally invasive procedures, chemotherapy, biological response modifier (BRM) therapy and injections.

Volume of procedures performed by Dr. Mark S. Box, MD for Medicare patients.

aspiration	288
biological response modifier (BRM) therapy	392
chemotherapy	392
doctor visit	2396
injections	308
minimally invasive procedures	774
musculoskeletal imaging	35
preventive care	80
vaccines	80
X-rays	35

2018 Medicare Patient Data

Information about Medicare patients treated by Dr. Mark S. Box, MD.

**Gender**
Male	165
Female	586

**Ethnicity**
Non-Hispanic White	640
Black	69
Hispanic	17
Asian	0
Other	0
Native American	0

**Age**
From 65 to 74	329
From 75 to 84	187
85 and over	57
Less than 65	178

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2018

Hypertension	64
High Cholesterol	55
Stroke	5
Ischemic Heart Disease	33
Depression	33
Chronic Kidney Disease	27
Asthma	11
Osteoperosis	18
Atrial Fibrilation	11
Heart Failure	18
Chronic Obstructive Pulmonary Disease	17
Diabetes	23
Dementia	11
Cancer	8

Medicare Procedure and Patient Information

2019 Medicare Procedure Volume

The top procedures that Dr. Mark S. Box, MD treated as a rheumatologist in Kansas City, MO during 2019 were minimally invasive procedures, chemotherapy, biological response modifier (BRM) therapy and injections.

Volume of procedures performed by Dr. Mark S. Box, MD for Medicare patients.

aspiration	272
biological response modifier (BRM) therapy	346
chemotherapy	346
doctor visit	2299
injections	304
minimally invasive procedures	770
musculoskeletal imaging	40
pain management	16
preventive care	117
vaccines	117
X-rays	40

2019 Medicare Patient Data

Information about Medicare patients treated by Dr. Mark S. Box, MD.

**Gender**
Male	146
Female	559

**Ethnicity**
Non-Hispanic White	594
Black	71
Hispanic	21
Asian	0
Other	0
Native American	0

**Age**
From 65 to 74	332
From 75 to 84	161
85 and over	60
Less than 65	152

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2019

Hypertension	64
High Cholesterol	58
Stroke	3
Ischemic Heart Disease	34
Depression	36
Chronic Kidney Disease	25
Asthma	11
Osteoperosis	21
Atrial Fibrilation	11
Heart Failure	18
Chronic Obstructive Pulmonary Disease	16
Diabetes	23
Dementia	10
Cancer	8

Medicare Procedure and Patient Information

2020 Medicare Procedure Volume

The top procedures that Dr. Mark S. Box, MD treated as a rheumatologist in Kansas City, MO during 2020 were minimally invasive procedures, chemotherapy, biological response modifier (BRM) therapy and injections.

Volume of procedures performed by Dr. Mark S. Box, MD for Medicare patients.

aspiration	205
biological response modifier (BRM) therapy	354
chemotherapy	354
doctor visit	2298
injections	226
minimally invasive procedures	816
musculoskeletal imaging	37
preventive care	89
vaccines	89
X-rays	37

2020 Medicare Patient Data

Information about Medicare patients treated by Dr. Mark S. Box, MD.

**Gender**
Male	139
Female	548

**Ethnicity**
Non-Hispanic White	581
Black	64
Hispanic	22
Asian	0
Other	0
Native American	0

**Age**
From 65 to 74	325
From 75 to 84	169
85 and over	56
Less than 65	137

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2020

Hypertension	61
High Cholesterol	57
Stroke	5
Ischemic Heart Disease	37
Depression	34
Chronic Kidney Disease	28
Asthma	10
Osteoperosis	25
Atrial Fibrilation	9
Heart Failure	17
Chronic Obstructive Pulmonary Disease	16
Diabetes	22
Dementia	9
Cancer	10

Medicare Procedure and Patient Information

2021 Medicare Procedure Volume

The top procedures that Dr. Mark S. Box, MD treated as a rheumatologist in Kansas City, MO during 2021 were minimally invasive procedures, chemotherapy, biological response modifier (BRM) therapy and injections.

Volume of procedures performed by Dr. Mark S. Box, MD for Medicare patients.

aspiration	198
biological response modifier (BRM) therapy	337
chemotherapy	337
doctor visit	2078
injections	216
minimally invasive procedures	756
musculoskeletal imaging	103
preventive care	115
vaccines	115
X-rays	103

2021 Medicare Patient Data

Information about Medicare patients treated by Dr. Mark S. Box, MD.

**Gender**
Male	136
Female	519

**Ethnicity**
Non-Hispanic White	556
Black	54
Hispanic	22
Asian	0
Other	0
Native American	0

**Age**
From 65 to 74	310
From 75 to 84	168
85 and over	54
Less than 65	123

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2021

Hypertension	60
High Cholesterol	57
Stroke	3
Ischemic Heart Disease	35
Depression	31
Chronic Kidney Disease	30
Asthma	9
Osteoperosis	27
Atrial Fibrilation	9
Heart Failure	14
Chronic Obstructive Pulmonary Disease	12
Diabetes	23
Dementia	9
Cancer	10

Medicare Procedure and Patient Information

2022 Medicare Procedure Volume

The top procedures that Dr. Mark S. Box, MD treated as a rheumatologist in Kansas City, MO during 2022 were minimally invasive procedures, chemotherapy, biological response modifier (BRM) therapy and aspiration.

Volume of procedures performed by Dr. Mark S. Box, MD for Medicare patients.

aspiration	157
biological response modifier (BRM) therapy	355
chemotherapy	355
doctor visit	1717
injections	157
minimally invasive procedures	607
musculoskeletal imaging	72
preventive care	73
vaccines	73
X-rays	72

2022 Medicare Patient Data

Information about Medicare patients treated by Dr. Mark S. Box, MD.

**Gender**
Male	120
Female	455

**Ethnicity**
Non-Hispanic White	496
Black	40
Hispanic	0
Asian	0
Other	18
Native American	0

**Age**
From 65 to 74	278
From 75 to 84	163
85 and over	43
Less than 65	91

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2022

Hypertension	69
High Cholesterol	71
Stroke	7
Ischemic Heart Disease	29
Depression	30
Chronic Kidney Disease	20
Asthma	13
Osteoperosis	33
Atrial Fibrilation	13
Heart Failure	14
Chronic Obstructive Pulmonary Disease	17
Diabetes	22
Dementia	5
Cancer	13

Medicare Procedure and Patient Information

Average Medicare Procedure Volume From 2012 - 2022

Volume of procedures performed by Dr. Mark S. Box, MD for Medicare patients.

The highest averages for the top procedures that Dr. Mark S. Box, MD treated as a rheumatologist in Kansas City, MO were lab tests, blood draw, minimally invasive procedures and chemotherapy.

aspiration	236
biological response modifier (BRM) therapy	509
blood draw	1251
chemotherapy	509
diabetes management	59
doctor visit	2311
hospital care	23
injections	277
inpatient care	23
lab tests	5091
minimally invasive procedures	785
musculoskeletal imaging	47
pain management	30
preventive care	234
thoracic (chest) imaging	17
thyroid function tests	159
vaccines	100
X-rays	55

Average Medicare Patient Data From 2012 - 2022

Information about Medicare patients treated by Dr. Mark S. Box, MD.

**Gender**
Female	573
Male	151

**Ethnicity**
Black / African American	75
Asian / Pacific Islander	0
Non-Hispanic White	614
Hispanic	15
Native American / Alaskan Native	0
Other	1

**Age**
85 and over	60
75 to 84	173
Less than 65	183
65 to 74	307

Average of Total of Conditions of Medicare patients treated by Dr. Mark S. Box, MD From 2012 - 2022

The highest averages of the most common conditions of Medicare patients that Dr. Mark S. Box, MD treated were hypertension, high cholesterol, ischemic heart disease and depression.

Hypertension	56
High Cholesterol	49
Stroke	4
Ischemic Heart Disease	28
Depression	27
Chronic Kidney Disease	21
Asthma	10
Osteoporosis	19
Heart Failure	13
Chronic Obstructive Pulmonary Disease	14
Diabetes	20
Atrial Fibrillation	9
Dementia	7
Cancer	7

Education & Training

Dr. Mark S. Box, MD graduated from University of Missouri-Columbia School of Medicine. He completed residency at Barnes-Jewish Hospital. He is certified by the Certification: Diplomate, American Board of Internal Medicine and has a state license in Missouri.

Medical School: University of Missouri-Columbia School of Medicine

Residency: Barnes-Jewish Hospital

Board Certification: Certification: Diplomate, American Board of Internal Medicine

Licensed In: Missouri

Affiliations & Hospitals

Dr. Mark S. Box, MD is associated with these hospitals and organizations:

St. Joseph Medical Center

Signature Medical Group

Ratings & Reviews

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General Payments

These charts describe general payments received by Dr. Mark S. Box, MD. Doctors may receive payments for a number of reasons, including meal compensation, travel compensation, and consulting.

**Payments by Company**
Amgen Inc.	$123,115 Enbrel $83,617	Tavneos $8,134	Prolia $4,668	Otezla $935	EVENITY $341	Other $25,420
Pfizer Inc.	$99,577 XELJANZ $58,588	INFLECTRA $26,483	LYRICA $12,689	PAXLOVID $447	EMBEDA $68	Other $1,303
Genentech USA, Inc.	$54,304 Actemra $54,161	Rituxan $139	$4
AbbVie, Inc.	$51,858 Humira $34,017	Lupron $4,763	Rinvoq $182	$12,896
GlaxoSmithKline, LLC.	$44,385 BENLYSTA $43,214	NUCALA $70	FLOVENT $59	TANZEUM $16	ANORO $14	Other $1,013
Other	$308,345 ACTHAR $45,872	ORENCIA $41,529	COSENTYX $38,253	Rinvoq $26,618	SAPHNELO $23,995	Other $132,078

**Types of Payments**
Compensation for services other than consulting, including serving as faculty or as a speaker at a venue other than a continuing education program	$465,723
Travel and Lodging	$82,609
Consulting Fee	$63,343
Food and Beverage	$51,799
Honoraria	$17,392
Other	$718

Research Payments

Dr. Mark S. Box, MD has received 26 research payments totaling $98,112.

Biography

Dr. Mark Box is an adult rheumatology specialist in Kansas City, MO. Clinical interests for Dr. Box include raynaud's, psoriatic arthritis, and fibromyalgia. He attended the University of Missouri-Columbia School of Medicine and subsequently trained at Barnes-Jewish Hospital for residency. His professional affiliations include Signature Medical Group and St. Joseph Medical Center.

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Dr. Mark S. Box, MD

Office Locations

Some issues Dr. Mark S. Box, MD can help you with:

Noteworthy Medicare Patient Procedures Performed by Dr. Mark S. Box, MD in 2023

By Volume:

By Volume:

Medicare Procedure and Patient Information

2012 Medicare Procedure Volume

Medicare Procedure and Patient Information

2013 Medicare Procedure Volume

2013 Medicare Patient Data

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2013

Medicare Procedure and Patient Information

2014 Medicare Procedure Volume

2014 Medicare Patient Data

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2014

Medicare Procedure and Patient Information

2015 Medicare Procedure Volume

2015 Medicare Patient Data

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2015

Medicare Procedure and Patient Information

2016 Medicare Procedure Volume

2016 Medicare Patient Data

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2016

Medicare Procedure and Patient Information

2017 Medicare Procedure Volume

2017 Medicare Patient Data

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2017

Medicare Procedure and Patient Information

2018 Medicare Procedure Volume

2018 Medicare Patient Data

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2018

Medicare Procedure and Patient Information

2019 Medicare Procedure Volume

2019 Medicare Patient Data

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2019

Medicare Procedure and Patient Information

2020 Medicare Procedure Volume

2020 Medicare Patient Data

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2020

Medicare Procedure and Patient Information

2021 Medicare Procedure Volume

2021 Medicare Patient Data

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2021

Medicare Procedure and Patient Information

2022 Medicare Procedure Volume

2022 Medicare Patient Data

Conditions of Medicare patients treated by Dr. Mark S. Box, MD in 2022

Medicare Procedure and Patient Information

Average Medicare Procedure Volume From 2012 - 2022

Average Medicare Patient Data From 2012 - 2022

Average of Total of Conditions of Medicare patients treated by Dr. Mark S. Box, MD From 2012 - 2022

Education & Training

Affiliations & Hospitals

Ratings & Reviews

General Payments

Research Payments

Biography

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